Red Blood Cell Membrane Dynamics during Malaria Parasite Egress
نویسندگان
چکیده
منابع مشابه
Arresting malaria parasite egress from infected red blood cells.
The cyclical waves of fever and chills associated with malaria result from the synchronous rupture of infected red blood cells (RBCs) that release swarms of parasites into the bloodstream for subsequent reinvasion and proliferation. Despite the clinical importance of this phase of the malaria parasite life cycle, relatively little is known about the mechanisms used by the parasite to promote RB...
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Egress of malaria parasites from the host cell requires the concerted rupture of its enveloping membranes. Hence, we investigated the role of the plasmodial perforin-like protein PPLP2 in the egress of Plasmodium falciparum from erythrocytes. PPLP2 is expressed in blood stage schizonts and mature gametocytes. The protein localizes in vesicular structures, which in activated gametocytes discharg...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2012
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2012.11.008